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Wanamaker has had an active career on stage since 1970, including the 1996 play Sylvia (as a dog); and more recently the female lead in Tennassee Williams' play The Rose Tattoo (at the National Theatre). She has become familiar to cinema-goers through such film roles as Madam Hooch in Harry Potter and the Sorcerer's Stone. In television, she voiced Lady Cassandra in the 2004 version of Doctor Who, and plays the recurring role of eccentric mystery novelist Ariadne Oliver in Poirot.