Like Sesame Street, it mixes puppets with animation and short films, along with child actors.
- In Season 2 episode 4 titled, "Justice," the puppet cast are seen as toddlers in animated form in a segment spoofing Muppet Babies called "Wonder Showzen Premies." The nursery even looks exactly the same as the original show. Other characters include a spoof Nanny, who wears the green and white striped stockings as the original one, but when we see how she looks above her legs, it is revealed she is just a big mouth with legs.
- Judah Friedlander played Crikey
- Zach Galifianakis played Uncle Daddy in "Mathematics"
- Jasmina Lee appeared in various Sesame Street-related productions.
- Christopher Meloni played a Cooties spokesman in the show's seventh episode.
- Amy Poehler appeared in two episodes.
- Amy Sedaris played Miss Amy, a storytelling fairy addicted to crack cocaine.
- Will Ryan was the voice of "Letter P" in episode 201.