He appeared on Muppets Tonight in episode 109 in a cameo appearance with Miss Piggy on an airplane, re-enacting a scene from his best known of two appearances on the original Twilight Zone. The scene also referenced his 1996 book Man o' War, which Piggy is reading. Shatner asks if she wants him to autograph the book, making it out to Babe.
In September 2015, Shatner commented on a CNN article reporting on Kermit the Frog's new girlfriend, Denise: "Wow! How much did this cost? BTW, is Miss Piggy available? #toosoon?"  The tweet generated a reply from Miss Piggy: "Very much available, mon cher. Gimme a call! I'd love to boldly go where no pig has gone before."  and Bill Prady: "Bill, as an Executive Producer of @TheMuppetsABC, I can officially tell you that @MissPiggy is “playing the field.”" 
Shatner's other television efforts range from hosting Rescue 911, guest spots on Gunsmoke and Mission: Impossible, and starring roles on T.J. Hooker (in the title role) and Boston Legal (as Denny Crane). Film credits include various Star Trek movies, Judgment at Nuremberg (with Burt Lancaster), and Miss Congeniality (with Sandra Bullock, Michael Caine, and Candice Bergen).