Notable landmarks include Nelson's Column, which stands in the center of the square. The column is topped by the statue of Admiral Horatio Nelson, hero of the Battle of Trafalgar, and reaches a total of 169 feet. Lion sculptures adorn the base. The square features other statues and monuments as well as the many fountains which decorate the area.
- In The Great Muppet Caper, Kermit, Fozzie, and Gonzo ride past in a London bus. Gonzo mistakes Nelson's Column for the Eiffel Tower, while Fozzie asks if bears are allowed in the fountains.
- In the third season Fraggle Rock episode "Blanket of Snow, Blanket of Woe," Uncle Traveling Matt visits Trafalgar square and climbs the lions at the base of Nelson's Column.
- Trafalgar Square is a featured level in the Great Muppet Caper portion of the video game Muppet Race Mania.