The Two-Headed Comic is a two-headed comedian from Muppets Tonight.

Clifford cues The Two-Headed Comic to stall time while he looks for Martin Short in episode 110.

The comedy pair tell a variation of the old "Who was that lady I saw you with last night?" joke. Rizzo tells Nigel that they found the Two-Headed Comic standing next to Bobo's nuclear-powered toaster (a scenario later replicated in It's a Very Merry Muppet Christmas Movie when Beaker accidentally duplicates his own head when coming in contact with rare mutagenic elements).

The puppet(s) had previously been used as Buster and Colfax Bergman in episode 105.