The Simpsons are the stars of the long-running animated series of the same name, created by Matt Groening. The family appeared in the celebrity version of the Sesame Street song "Monster in the Mirror." The Simpsons replace two monsters on a wall painting, and at the end, Homer reprimands Bart (who yells "Hey, Wubba man!" to Grover). The show's voice cast are heard in the segment (Dan Castellaneta as Homer, Julie Kavner as Marge, Nancy Cartwright as Bart, and Yeardley Smith as Lisa).
The Simpsons has also made many references to the Muppets and Sesame Street.
| || Black Widower|
| Homer, Bart, Lisa and Maggie are watching an episode of Dinosaurs on TV. The parody clip shown of a "Simpson-ized" Earl, Robbie and Baby hints at the fact that the show was perceived in some quarters as another Simpsons-clone.
In the DVD audio commentary on this episode, Mike Reiss comments, saying "Look, it's a parody of Dinosaurs! I'm sure none of you remember this show. It came on, I guess, this year and they were giant kind of foam-rubber dinosaurs with human beings inside. I think the Jim Henson Company made them. And it was really kind of a character-for-character knock-off of The Simpsons. And so we took a shot at them. But you see it today and you don't know what we're talking about."
| Bart the Fink|
| When Krusty fakes his own death, Simpsons writer John Swartzwelder is seen in the crowd of the funeral holding a Kermit puppet that is smoking.
Swartzwelder appeared with Kermit again in a Simpsons poster. 
| || A Fish Called Selma|
| Troy McClure (voiced by Phil Hartman) stars in a fictional Muppet movie entitled "The Muppets Go Medieval" with Kermit the Frog and Miss Piggy. The Simpson family watches the movie on TV at the beginning on the episode, and later it is seen again on Troy and Selma's date to the drive-in.
Later at the drive-in, on the screen, Troy (as Sir Lies-alot) rides on a horse, and later, as Troy proposes to Selma, they both echo the same dialogue from the movie playing on screen...
| Miracle on Evergreen Terrace|
|Milhouse tells Bart that he's gotten a "Tickle-me-Krusty" (a play on the Tickle-me-Elmo).|
| || Trash of the Titans|
|In the musical number "The Garbage Man Can," Oscar pops out of one of the trash cans.|
| || Missionary: Impossible|
| When Homer scams the PBS telethon, an angry crew chases after him demanding money. Included in the PBS mob are Fred Rogers, Yo-Yo Ma, the Teletubbies, Big Bird (who angrily squawks like a real bird), Oscar and Elmo.
| Moe Baby Blues|
|When babysitting Maggie, Moe says that "You can't tickle Elmo no more." He then pulls an Elmo doll off the shelf. When he tries to tickle it, it says "No means no for Elmo!" and slaps him.|
| Bart-Mangled Banner|
|When the Simpsons are in prison for being unpatriotic, Lisa points out several celebrities who are there as well including Michael Moore, the Dixie Chicks, Elmo and President Bill Clinton. Elmo admits that "Elmo go to wrong fundraiser!" Later, when they make their escape and swim in the ocean, Homer says, "I don't wanna end up like Elmo, hanging myself in a cell."|
| The Girl Who Slept Too Little|
|Marge admits her dislike towards The Count and a clip of him counting coconuts in his castle is shown on the TV. When the Count laughs (in a scary, ghoulish laugh instead of his trademark laugh) Marge gets upset and yells, "Go back to your own country!"|
| Stop Or My Dog Will Shoot|
|Police Chief Wiggum admits that he likes to knit violent imagery, and he shows the family a blue sweatshirt he made featuring Big Bird killing Elmo in a saw mill.|
| Funeral For a Fiend|
|Moe accidentally breaks his plasma-screen TV after buying it at Circuit Circus, so he goes back to his old routine of watching DVDs in family vans. He runs after the Hibberts' van: "Big Bird in China? Won't Grover get lonely? ... Oh, no, wait, he's hanging out with Derek Jeter."|
| Dial N For Nerder|
|Maggie is seen playing poker online, but quickly switches over to an education site featuring Elmo when she realizes the family may be watching her.|
| Papa Don't Leech|
|On TV, country singer Lurleen Lumpkin (voice of Beverly D'Angelo) is singing to Kermit the Frog wearing a cowboy hat. Lurleen suggests bunking with Kermit that night, and before Kermit can make his decision, Miss Piggy kicks Kermit off the fence and begins choking him in Homer-style.|
| Mona Leaves-A|
|During a televised ESPY awards broadcast, Lance Armstrong (voicing himself) and Fozzie Bear co-present an award sponsored by Right Guard deodorant. After a typical corny joke from Fozzie at Armstrong's expense, he angrily throws the Fozzie puppet across the room, revealing the puppeteer's hand underneath.|
| Gone Maggie Gone|
|Homer discovers rats in the kitchen, including one riding an eggbeater.|
| Eeny Teeny Maya Moe|
|During overtime of a hockey game, costume versions of Big Bird, Elmo and Count von Count are seen waiting to begin their "Sesame Street on Ice" show.|
| Thursdays with Abie|
|A poster for a stage adaptation of "Out of the Mouth of Abe", a parody of "Tuesdays with Morrie", says that Grandpa Simpson was created by Jim Henson's Creature Shop.|
| The Color Yellow|
|Ralph Wiggum displays a drawing for his Black History Month presentation: "Martin Luther King had a dream! Dreams are where Elmo and Toy Story had a party and I went there!"|
| To Surveil With Love|
|Marge works in a room with surveillance monitors showing all of Springfield, and Maggie is seen watching what she thinks is Sesame Street but is actually a gay bar, complete with men resembling Bert, Ernie, Big Bird, and Oscar the Grouch.|
| Treehouse of Horror XXI|
|A number of famous vampires are seen in a Twilight parody, including a parody of The Count (who is shown sucking Big Bird's blood). Homer stops to ask if he's seen his daughter and her vampire boyfriend, to which the Count begins counting the number of times they kissed.|
| || The Fight Before Christmas|
| The final segment of the episode features Maggie dreaming of the family as |
| The Food Wife|
November 13, 2011
| During a dream sequence Marge has, a line of famous chefs follow Homer on moon-bouncer toys, including Wolfgang Puck, Harland Sanders and The Swedish Chef. When they agree "everything's more fun with Homer," the Chef sings in mock Swedish about Homer.
The three can also be seen in a promotion image for the episode with Marge, Lisa and Bart.
| Politically Inept, with Homer Simpson|
January 8, 2012
|When Homer is offered a job as a political pundit, the network executive shows him a clip of their liberal straw man. He sings a song to the tune of "If I Only Had a Brain" on a set with a green, lizard-like creature playing the banjo and a thought bubble reading "It's Not Easy Being a Democrat".|
| The Spy Who Learned Me|
May 6, 2012
|When Lenny comes into Moe's Tavern, Stradivarius Cain hides under a pool table because other people's imaginary friends can see him. A parody of Mr. Snuffleupagus called Huffnpuffalus apologizes for sleeping with Cain's girlfriend. He is later seen near the end of the episode when he is shot by Cain and knew that Cain was mad at him.|
| Lisa Goes Gaga|
May 20, 2012.
|Lady Gaga's infamous outfit made of Kermit dolls is seen on her costume rack.|
| Love is a Many-Splintered Thing|
February 10, 2013
|Cletus shows his list of people to feud with (in the stereotypical hillbilly style), one of them being "Those Dang Muppets."|
| Black-Eyed, Please|
March 10, 2013
|Ned Flanders returns home from a power walk to find his parents with Homer, high on marijuana and laughing at a parody version of Big Bird on TV, talking with a smaller yellow "Muppet" standing behind the infamous brick wall setting.|
| Pulpit Friction|
April 28, 2013
|Bart and Milhouse lure hundreds of frogs away from the swamp and into the city. Dozens of them pass by Kermit the Frog, revealed as a puppet when Jim Henson and Frank Oz emerge from behind a rock and flee from the amphibious stampede.|
| Let's Go Fly a Coot|
May 3, 2015
|Milhouse is having a huge birthday party, and he complains about the cheese slices his father Kirk has prepared, saying he wanted Pokémon characters. He holds up a cheese slice vaguely resembling Kermit the Frog's head, and Kirk says he thought Milhouse wanted cheese slices of "Disney's Muppets."|
| Halloween of Horror|
October 18, 2015
|Police officers Lou and Eddie dress up as Bert and Ernie for Halloween, respectively. Additionally, earlier in the episode, Homer tells Ned Flanders as part of their Halloween plans about a fictional Treehouse of Horror special they'll be doing, including spoofing The Muppets' Wizard of Oz, with Homer as "Scarecrow Fozzie."|
| Lisa with an "S"|
November 22, 2015
|During a montage of Moe and his friend Laney hanging out in New York, at one point they are chased by a "fake" Muppet costumed character, referencing the fake Sesame Street costumed characters appearing in Manhattan (and resembling a purple Elmo.) Soon the "Muppet"'s family joins in the chase, wielding baseball bats.|
| Friends and Family|
October 2, 2016
|Mr. Burns talks about how he has led quite a life, and he looks at the hunting trophies in his office, including a parody of Big Bird's head mounted with the other trophies.|
- Brother From The Same Planet (February, 1993) - Homer walks down a street and notices a homeless guy in a dumpster to which he exclaims "Heh heh, just like Oscar the Grouch!'
- The Twisted World of Marge Simpson (January, 1997) - In a deleted scene, Marge tells Homer to "name one thing that was ever helped by mob ties." Homer mentions Las Vegas, boxing, football, and Children's Television Workshop.
- My Sister, My Sitter (March, 1997) - Ned Flanders tells Homer that he's got a "Fozzie of a Bear of a problem."
- The Old Man and the "C" Student (April 25, 1999) - While cleaning the town, Chief Wiggum calls one of the fleeing rats "Rizzo".
- Grift of the Magi (December, 1999) - The head of a toy company says that they have a hard time "coming up with the new Furby or Tickle-me-Elmo."
- Brawl in the Family (January, 2002) - At a meeting of the Springfield Republicans, Krusty the Clown suggests that they get rid of PBS because "those lousy Muppets" have been taking up his airtime.
- Blame it on Lisa (March, 2002) - The Simpsons fly to Brazil in search of Lisa's pen pal Ronaldo. While staying at a hotel, Bart watches a "children's show" entitled Teleboobies with scantily clad female dancers, a walkaround pineapple, a lizard and a tall flamingo. Marge shows her disgust for the sexuality saying, "Bert and Ernie left it to your imagination."
- You Kent Always Say What You Want (May, 2007) - At Spinster City Apartments, Marge plays a guessing game with the pictures that Maggie drew. One of the guesses that Marge makes about Maggie's drawings was Elmo.
- E Pluribus Wiggum: (January, 2008) - Springfield elects Ralph Wiggum for president. Since Ralph hasn't chosen to be either Republican or Democrat, Chief Wiggum tries to help him make up his mind, stating that the Republican party's mascot is an elephant, and the Democrats mascot is a donkey. When asking who he likes better, Ralph says that he likes Elmo. On a talk show, it is asked if Ralph can go from Sesame Street to Pennsylvania Avenue.
- How the Test Was Won : (March, 2009) - In Capitol City, Ralph Wiggum ends up on a garbage barge. A rat scurries all over him, which he claims to be Elmo.
- The Blue and the Gray : (February, 2011) - While Marge and Lisa were running after Lisa's macaroni Marconi, Milhouse wonders if Marge's hair makes her sees something scary like the vampire on Sesame Street.
- The Great Simpsina : (April, 2011) - While attempting to dump a whole load of peaches somewhere, Lisa finds herself lost in a run-down, old-fashioned-looking neighborhood, and she comments that the area is starting to look like Sesame Street. She then notices a trash can rattling, and wonders if maybe Oscar the Grouch is inside, but then the lid bursts open and a raccoon hisses at her, causing her to run away screaming.
- Bart Stops to Smell the Roosevelts : (October, 2011) - Bart Simpson and several of his friends are taking over the school, resulting in the police and the SWAT Team arriving. When officer Lou asks if they can take on a whole school building without hurting any kids, Chief Wiggum mentions that the Muppets were able to take Manhattan.
- The D'oh-cial Network : (January, 2012) - Rev. Lovejoy takes a "What Muppet are you?" quiz, the result being Beaker.
- Moonshine River : (September, 2012) - When the brother of Bart's former wife Mary (sibling of Cletus Spuckler) tells him and Milhouse that she ran off to New York City, Milhouse asks if that's where Sesame Street is located, and wonders what happens to Oscar the Grouch on trash day.
- Gone Abie Gone : (September, 2012) - At Moe's Tavern, when discussing the money Homer earned from a lawsuit involving an onion ring accident, Lenny warns that banks can be tricky, because Kermit the Frog warned about it on Sesame Street, and that he "was wearing his trenchcoat." Homer asks in disbelief, "The frog in the trenchcoat is Kermit, too?" Lenny says that all the frogs on Sesame Street are Kermit, as it keeps the other frog actors out of work.
- Specs and the City : (January, 2014) - At the Nuclear Power Plant, two workers wearing their hi-tech glasses that Mr. Burns gave them are playing a virtual game of Muppet Chess. When one of them manages to beat the other with his Fozzie piece, he gets a "Kermit-mate" and proudly says "Wocka-wocka!"
- Diggs : (March, 2014) - A new transfer student at Springfield Elementary, Diggs (voiced by Daniel Radcliffe), has just saved Bart from the school bullies with his falcon. Among learning Bart is known across the school as the "kid that ate the frog," Diggs says that is probably the reason why they have to dissect a Muppet in biology class.
- The Burns Cage: (April, 2016) - Milhouse, when deciding to audition for the part of Rick in a school production of Casablanca, mentions that co-stars always fall in love, like Kermit and Miss Piggy.
- Simpsons Comics #43: (June 1999) - The supporting comic story (written and drawn by Scott Shaw!), features pitches for spin-offs featuring Poochie the Dog (a failed Itchy and Scratchy character). One of them is a parody of Muppet Babies, entitled "Poochie Babies" and featuring Li'l Poochie (in Baby Kermit's role), along with his friends Whiney Swiney, Spazzy Bear, Alonzo the Watchamacallit, Meowwlf, Baby Bestial and the twins, Skidmark and Scurvy. They are watched over by Manny, a sleazy male whose face isn't shown, ala Nanny.
- Simpsons Comics #72: (April 2002) - In the comic "Secret Origin of Sideshow Mel," Mel states that "All the best sidekick jobs are going to either drunkards or Muppets."
- Simpsons Comics #106: (May 2005) - In the story "Simpsons: the Musical," the family, stars of their own stage musical, meets up with several other musical performers, including two puppeteers from "Puppet Street, the Musical," a parody of both Sesame Street and Avenue Q (itself a parody of Sesame Street). Both puppeteers have parodies of Ernie and Bert with them.
- Simpsons Comics #175: (Febuary 2011) - Homer fantasizes and tells a complete parody of The Muppet Show, with Lisa as Kermit, Bart as Gonzo, Krusty as Fozzie, Grandpa and Jasper as Statler and Waldorf, and Barney as Sweetums. Sesame Street and Fraggle Rock are mentioned as well.
- Radioactive Man 80-Page Colossal: (August 1995) - In the comic story "The 1,001 Faces of Radioactive Ape" (also written and drawn by Scott Shaw!), at one point Radioactive Man's simian counterpart mutates into a gigantic baby version of himself. One of the "gibberish" sounds he makes is "wokka-wokka!"
- Bart Simpson #30: (June 2006) - In the comic "The Book That Ate Springfield" after having his show with no viewers because of his promoting to read the Larry Snotter book, Krusty exclaims "Lousy 'Sesame Street!' Oooh, let's teach the children to REEEAD! I WARNED them they were killin' the golden goose!"
- In the Dinosaurs episode "Dirty Dancin'," the show's writers commented on the comparison drawn between Dinosaurs and The Simpsons. In one scene Earl observes that TV stinks because when "one show's a hit, they make fifty more like it with the same characters and the same premise." Baby then quotes Bart Simpson's popular catchphrase of the time, "Don't have a cow, man!"
- On Farscape, John Crichton, always ready to display his pop-culture knowledge to uncomprehending aliens, twice referenced The Simpsons during the fourth season, in both cases in the second half of a multi-part story. In "What Was Lost: Resurrection," Crichton greets Grayza with "Bad news from Smithers?", likening Braca to the toadying assistant to Mr. Burns on The Simpsons. In an inversion of the same allusion, during the second part of the "We're So Screwed" storyline "Hot to Katratzi," Crichton shouts "Feel the love, Mr. Burns!" to Scorpius. In interviews, actor David Franklin, who played Braca, admitted to being a Simpsons fan and joking about the Smithers similarity.
- A season 45 episode of Sesame Street features a Muppetized version of Comic Book Guy performed by Martin P. Robinson, who consistently calls "Numeric-Con" the "worst convention ever."
- Santa's Little Helper, the Simpsons family dog, was included on Animal Planet's 50 Greatest TV Animals along with Kermit and Big Bird.
- On May 15, 2016, the show promoted "Homer Live," a stunt in which viewers were able to ask Homer Simpson questions live on the air and via Twitter. Homer responded to a Twitter question about who his favorite Muppet is by tweeting: "Miss Piggy She's sexy and she's bacon."
- Hank Azaria plays Moe Syzlak, Chief Wiggum, Apu Nahasapeemapetilon, Carl Carlson, Dr. Nick Riviera, Professor Frink, Comic Book Guy, Superintendent Chalmers, Cletus Spuckler, Disco Stu, Duffman, and others
- Nancy Cartwright plays Bart Simpson, Nelson Muntz, Ralph Wiggum, Todd Flanders, Kearny, and others
- Dan Castellaneta plays Homer Simpson, Grandpa Simpson, Krusty the Clown, Groundskeeper Willie, Itchy the Mouse, Mayor Quimby, Barney Gumble and others
- Kelsey Grammer plays Sideshow Bob Terwilliger
- Julie Kavner plays Marge Simpson, Patty and Selma Bouvier, and Jacqueline Bouvier
- Jon Lovitz plays Artie Ziff, Jay Sherman, Llewelyn Sinclair, Aristotle Amadopolis, Professor Lombardo, Enrico Irritazio and others
- Kevin Michael Richardson plays various background characters
- Harry Shearer plays Mr. Burns, Waylon Smithers, Ned Flanders, Reverend Lovejoy, Kent Brockman, Dr. Hibbert, Principal Skinner, Otto Mann, Scratchy the Cat, Lenny Leonard, Rainier Wolfcastle and others
- Yeardley Smith plays Lisa Simpson
- Russi Taylor plays Martin Prince, Sherri and Terri, Uter and others
- Frank Welker plays Santa's Little Helper and provides other animal and creature sounds
- Bob Kushell was a credited writer of 2 episodes
- Tom Martin was a credited writer of 3 episodes
- Bobby Lopez composed and co-wrote the song "Enjoy It While You Can" for "A Totally Fun Thing That Bart Will Never Do Again"
- Conan O'Brien was a credited writer of 4 episodes
- Nell Scovell was a credited writer of 1 episode
- Scott Shaw! has written and illustrated many issues of Simpsons Comics.
- Patric Verrone was a credited writer of 1 episode
- Tom Arnold voiced himself in "Treehouse of Horror X"
- Andre Agassi played himself in "Tennis the Menace"
- Marv Albert played himself in "The Burns and the Bees"
- Buzz Aldrin voiced himself in "Deep Space Homer"
- Steve Allen played himself in "Separate Vocations" and "Round Springfield"
- Edward Asner played the editor of the Springfield Shopper in "Guess Who's Coming to Criticize Dinner"
- Alec Baldwin played himself in "When You Dish Upon a Star" and Caleb Thorn in "Bonfire of the Manatees"
- Anne Bancroft played Dr. Zweig in "Fear of Flying"
- Drew Barrymore played Sophie in "Insane Clown Poppy"
- Jason Bateman played himself in "Home Away From Homer"
- Tony Bennett played himself in "Dancin' Homer" and "Bart vs. Lisa vs. The Third Grade"
- Greg Berg played Rory the bum in "Bart vs. Thanksgiving"
- Jack Black played Milo in "Husbands and Knives"
- Albert Brooks played Cowboy Bob in "Call of the Simpsons," Jacques in "Life in the Fast Lane", Brad Goodman in "Bart's Inner Child", Hank Scorpio in "You Only Move Twice", Tab Spangler in "The Heartbroke Kid," and Russ Cargill in The Simpsons Movie
- Mel Brooks played himself in "Homer vs. Patty & Selma"
- Pierce Brosnan played the Ultrahouse 3000 and himself in "Treehouse of Horror XII"
- Peter Buck played himself in "Homer the Moe"
- Jack Burns played Edward Christian in "Beyond Blunderdome"
- Johnny Carson played himself in "Krusty Gets Kancelled"
- Johnny Cash played the Coyote in "El Viaje Misterioso de Nuestro Jomer"
- Kim Cattrall played herself in " Brother, Where Bart Thou?" (2009)
- Dick Cavett played himself in "Homie the Clown"
- Dick Clark played himself in "Treehouse of Horror X"
- Clarence Clemons played the narrator in "Grift of the Magi"
- Glenn Close played Mona Simpson in four episodes
- Stephen Colbert played Colby Kraus in "He Loves to Fly and He D'ohs"
- Shawn Colvin played Rachel Jordan in "Alone Again, Natura-Diddly" and "I'm Goin' to Praiseland"
- Tim Conway voiced himself in "The Simpsons Spin-Off Showcase"
- Rodney Dangerfield played Larry Burns in "Burns, Baby Burns"
- Ted Danson played Sam Malone in "Fear of Flying"
- Danny DeVito played Herbert Powell in "Oh Brother, Where Art Thou?" and "Brother Can You Spare Two Dimes?"
- The Dixie Chicks played themselves in "Papa Don't Leech"
- Plácido Domingo played himself in "The Homer of Seville"
- Fran Drescher played the Female Golem in "Treehouse of Horror XVII"
- Artie Esposito puppeteered in "The Fight Before Christmas"
- Harvey Fierstein played Karl in "Simpson and Delilah"
- Jodie Foster played Maggie Simpson in "Four Great Women and a Manicure"
- Dennis Franz played himself playing Homer Simpson in "Homer Badman"
- Lady Gaga played herself in "Lisa Goes Gaga"
- Jennifer Garner played herself in "Treehouse of Horror XIV"
- Ricky Gervais played Charles in "Homer Simpson, This Is Your Wife"
- Mel Gibson played himself in "Beyond Blunderdome"
- Kathie Lee Gifford played herself in "Treehouse of Horror IX"
- Jeff Goldblum played MacArthur Parker in "A Fish Called Selma"
- John Goodman played Meathook in "Take My Wife, Sleaze"
- Elliott Gould played himself in "The Dad Who Knew Too Little"
- Kathy Griffin played Francine in "Bye Bye Nerdie"
- Melanie Griffith played herself in "The Monkey Suit"
- Mark Hamill played himself and Leavalle in "Mayored to the Mob"
- Tom Hanks played himself in The Simpsons Movie
- Neil Patrick Harris played himself as the actor playing Bart Simpson in "Bart the Murderer"
- Anne Hathaway played Jenny in "The Good, the Sad and the Drugly"
- Tony Hawk played himself in "Barting Over"
- Bob Hope played himself in "Lisa the Beauty Queen"
- Ron Howard played himself in "When You Dish Upon a Star", "Hello Gutter, Hello Fadder"
- Joshua Jackson played Jesse Grass in "Lisa the Tree Hugger"
- Michael Jackson played Leon Kompowsky in "Stark Raving Dad"
- Mick Jagger played himself in "How I Spent My Strummer Vacation"
- Penn Jillette played himself in "Hello Gutter, Hello Fadder"
- Elton John played himself in "I'm With Cupid"
- James Earl Jones played the moving man, Serak the Preparer, and narrator in "Treehouse of Horror", Evil Maggie in "Treehouse of Horror V", and narrator in "Das Bus"
- Larry King played himself in "One Fish, Two Fish, Blowfish, Blue Fish" and "Sideshow Bob Roberts"
- Cyndi Lauper played herself in "Wild Barts Can't Be Broken"
- Cloris Leachman played Mrs. Glick in "Three Men and a Comic Book"
- Stan Lee played himself in "I Am Furious Yellow"
- Jay Leno played himself in "The Last Temptation of Krust"
- Little Richard played himself in "Special Edna"
- Julia Louis-Dreyfus played Gloria in "I Don't Wanna Know Why the Caged Bird Sings"
- Yo-Yo Ma played himself in "Puffless"
- William H. Macy played himself in "Homer's Paternity Coot"
- Penny Marshall played Ms. Botz in "Some Enchanted Evening"
- Andrea Martin played Mama Nahasapeemapetilon in "The Two Mrs. Nahasapeemapetilons"
- Steve Martin played Ray Patterson in "Trash of the Titans"
- Phil McGraw played himself in "Treehouse of Horror XVII"
- Michael McKean played David St. Hubbins in "The Otto Show" and Jerry Rude in "Monty Can't Buy Me Love"
- Bret McKenzie played Kurt in "Elementary School Musical"
- Ed McMahon played himself in "Treehouse of Horror IX"
- Sam McMurray played a wormer in "Homer's Odyssey" and Gulliver Dark in "Homer's Night Out"
- Bette Midler played herself in "Krusty Gets Kancelled"
- Mike Mills played himself in "Homer the Moe"
- Mr. T played himself in "Today I am A Clown"
- *NSYNC played themselves in "New Kids on the Blecch"
- Joe Namath played himself in "Bart Star" (1997)
- Liam Neeson played Father Sean in "The Father, The Son, and The Holy Guest Star"
- Sam Neill played Malloy the cat burgler in "Homer the Vigilante"
- Willie Nelson played himself in "Behind the Laughter"
- Bob Newhart played himself in "Bark the Fink"
- Paul Newman played himself in "The Blunder Years"
- Leonard Nimoy played himself in "Marge vs. the Monorail" and "The Springfield Files"
- Conan O'Brien played himself in "Bart Gets Famous"
- Dolly Parton played herself in "Sunday, Cruddy Sunday"
- Mandy Patinkin played Hugh Parkfield in "Lisa's Wedding"
- Rhea Perlman played Carla Tortelli in "Fear of Flying"
- Katy Perry guest starred in "The Fight Before Christmas"
- Michelle Pfeiffer played Mindy Simmons in "The Last Temptation of Homer"
- Regis Philbin played himself in "Treehouse of Horror IX"
- Natalie Portman played a teenaged girl in "Little Big Girl"
- Wolfgang Puck played himself in "The Bart Knows What It Wants"
- Tito Puente played himself in "Who Shot Mr. Burns?"
- Daniel Radcliffe played Edmund in "Treehouse of Horror XXI" and Diggs in "Diggs"
- Dan Rather played himself in "E Pluribus Wiggum"
- Tim Robbins played Jim Hope in "Grift of the Magi"
- Ray Romano played Ray Magini in "Don't Fear the Roofer"
- Linda Ronstadt played herself in "Mr. Plow
- Isabella Rossellini played Astrid Weller in "Mom and Pop Art"
- Susan Sarandon played the ballet teacher in "Homer vs. Patty & Selma" and herself in "Bart Has Two Mommies"
- Martin Sheen played Sgt. Seymour Skinner in "The Principal and the Pauper"
- Brooke Shields played herself in "The Front"
- Dick Smothers played himself in "O Brother, Where Bart Thou?" (2009)
- Jerry Springer played himself in "Treehouse of Horror IX" (1998)
- Ringo Starr played himself in "Brush with Greatness"
- Jon Stewart played himself in "E Pluribus Wiggum"
- Patrick Stewart played Number One in "Homer the Great"
- Ben Stiller played Garth Motherloving in "Sweets and Sour Marge"
- Michael Stipe played himself in "Homer the Moe"
- George Takei played Akira the waiter in "One Fish, Two Fish, Blowfish, Blue Fish," Wink the Japanese game show host in "Thirty Minutes Over Tokyo," and the waiter in "A Hunka Hunka Burns in Love"
- Amy Tan played herself in "Insane Clown Poppy"
- Elizabeth Taylor played Maggie Simpson in "Lisa's First Word" and played herself in "Krusty Gets Kancelled"
- James Taylor played himself in "Deep Space Homer"
- Teller played himself in "Hello Gutter, Hello Fadder"
- Dave Thomas played Rex Banner in "Homer vs. The Eighteenth Amendment"
- Marisa Tomei played Sara Sloane in "A Star is Born-Again"
- Lily Tomlin played Tammy in "The Last of the Red Hat Mamas"
- Alex Trebek played himself in "Miracle on Evergreen Terrace" and "When You Dish Upon a Star"
- Dick Tufeld played the Lost in Space Robot in "Mayored to the Mob" and "Milhouse Doesn't Live Here Anymore"
- Kathleen Turner played Stacy Lovell in "Lisa vs. Malibu Stacy"
- Steven Tyler played himself in "Flaming Moe's"
- Tracey Ullman played Emily Winthrop in "Barts Dog Gets an F"
- Gedde Watanabe played the Mr. Sparkle factory foreman in "In Marge We Trust" and a Japanese father in "Thirty Minutes Over Tokyo"
- George Wendt played Norm Peterson in "Fear of Flying"
- Betty White played herself in "Missionary: Impossible" and "Homerazzi"
- Fred Willard played Wally Kogen in "Sunday, Cruddy Sunday"
- Venus Williams played herself in "Tennis the Menace"
- Henry Winkler played Ramrod in "Take My Wife, Sleaze"
- Reese Witherspoon voiced Greta Wolfcastle in "The Bart Wants What It Wants"
- "Weird Al" Yankovic played himself in "Three Gays of the Condo" and "That 90's Show"