The Patty Duke Show is a sitcom that aired on ABC from 1963 until 1966. The series starred Patty Duke as identical twin cousins Patty and Cathy Lane.
Muppets Tonight spoofed the comedy as "The Ratty Duke Show." Rizzo the Rat wears a cast jacket sporting the name of the series, depicting twin rats. Also in episode 203 in the segment, Tales from the Vet, Mulch plays the theme song of this show as the closing music.
- James Coco played the director in "Patty Meets a Celebrity" (1964)
- George Gaynes played Gaylord in "The Perfect Hostess" (1965)
- Bruce Kirby played a theatre manager in "Little Brother Is Watching You" (1965) and Mr. Haley in "Patty the Folk Skinger" (1965)
- Margaret Hamilton played a maid in "Double Date" (1963) and Mrs. Williams in ""Let 'Em Eat Cake" (1964)
- Skip Hinnant played Ted (six episodes, 1963-1965)
- William Schallert played Martin Lane
- John Spencer played Henry (seven episodes, 1963-1964)
- Jean Stapleton played Mrs. Pollock in "The Raffle" (1965)
- Jon Stone played a talent scout (Ryan) in "The Actress" (1963)