The Old Woman Who Lives in a Shoe is the title character of a well-known nursery rhyme, There was an Old Woman Who Lived in a Shoe. As her name suggests, she lives in a giant shoe (a size 59 triple-E, by Kermit's approximations). She is the mother of many children (so many that she doesn't know what to do). She has appeared multiple times on Sesame Street.
In her earliest known appearance (in a "News Flash" segment), she is played by Frank Oz. When Kermit arrives at her house, she quickly, and without asking, puts him in charge of babysitting so she can go bowling. (She is a member of the Gray Panthers Bowling League.) Her house is located next to the Young Woman Who Lives in a Hat. In this segment, seven of her children are named. She tells Heather and Johnny not to fight; Brian, Lisa and Cheryl not to watch too much television; and Polly and Kate to go to bed when the frog says. The first five children named hold the same first names as Jim and Jane Henson's five children, and Polly and Kate are named after Jon Stone's children.
In a later appearance (played by Kathryn Mullen), she contradicts the News Flash as she visits the office of Mother Goose due to nursery rhyme problems; Mother Goose had trouble coming up with her poem's ending. Once again at the end of the sketch, she dumps her kids and leaves them at Mother Goose's office (which they wreck and adorn with crumpled paper and paper airplanes).
She later appeared (as a Hot Pink Anything Muppet) performed by Fran Brill in a season 45 episode. She's seen driving a shoe-shaped car and has 12 rambunctious kids named Ed, Fred, Ned, Ted, Jed, Red, Nan, Jan, Ann, Fran, Zan and Marcelo.