The Empire State Building is a 102-story building in the heart of New York City.
- In The Muppets Take Manhattan, Kermit the Frog yells from the building's observation deck to prove his dedication to staying in New York and working on the Muppets' Broadway show.
- Quongo the gorilla sings "It's Lonely at the Top" for the UK Spot of episode 403 of The Muppet Show from the building.
- Baby Animal climbed the Empire State Building in a Muppet Babies King Kong spoof in "Piggy's Hyper-Activity Book".
- The book What's a Fraggle? features Uncle Traveling Matt in a backdrop of New York City, and the Empire State Building.
- Big Bird sees a rock formation that is as tall as the building in the book Big Bird Visits Navajo Country.
- On April 2, 2014, for World Autism Awareness Day, Abby Cadabby lit up the Empire State Building in blue, joined by Autism Speaks co-founders Suzanne Wright and Bob Wright.
- Miss Piggy's appearance in the Kate Spade New York web series, #missadventure takes place in an elevator in the building.
- The Empire State Building features a film entitled "New York Skyride," (narrated by Kevin Bacon) which has several movie posters in the waiting area, including King Kong and The Muppets Take Manhattan.