Take Two with Phineas and Ferb was a series of Disney Channel interstitials which ran from 2010 to 2011, featuring the animated stars of the series Phineas and Ferb interviewing various celebrities.
A segment guest starring Miss Piggy debuted on ABC on August 20, 2011 during the network television premiere of the made-for-TV movie Disney's Phineas and Ferb the Movie: Across the Second Dimension. It first aired on Disney Channel on September 9, 2011, following the channel's premiere of Pixar's Up. In the segment, Miss Piggy shows off her karate skills by making an ice sculpture of herself and raps "Spa Day."
A number of other celebrities that Phineas and Ferb have interviewed have also performed with Muppets, including David Beckham, Tom Bergeron, Jack Black, Cedric the Entertainer, Neil Patrick Harris, Tony Hawk, Randy Jackson, Larry King, Howie Mandel, Ty Pennington, Regis Philbin, Andy Samberg, Jason Segel, and Ben Stiller.
- In Tales of a Sixth-Grade Muppet, Danvers' sister Chloe imagines several business plans for him, one of them being the show Phineas and
- In the Phineas and Ferb episode "Robot Rodeo," at one point, Linda repeats a mantra of "Cake is a sometimes food", a parody of "A Cookie is a Sometime Food."
- Tom Bergeron voiced L.O.V.E.M.U.F.F.I.N. Pageant of Evil Host in the episode "Bullseye!" (2011)
- Joan Cusack voiced Glenda in the episode "Last Train to Bustville" (2011)
- Billy Ray Cyrus voiced Buck Buckerson in the episode "It's A Mud, Mud, Mud, Mud World" (2008)
- Tina Fey voiced Annabelle Johnson in the episode "Run, Candace, Run" (2011)
- Michael J. Fox voiced Michael in the episode "The Curse of Candace" (2011)
- Joel Grey voiced Beppo Brown in the episode "Oil on Candace" (2008)
- Phill Lewis voiced a hotel manager in the episode "Phineas and Ferb Hawaiian Vacation" (2010)
- Evander Holyfield voiced himself in the episode "Raging Bully" (2008)
- John O'Hurley voices Mayor Roger Doofenshmirtz
- Allison Janney voices Charlene Doofensmirtz
- Jay Leno will voiced Colonel Contraction in the episode "Phineas and Ferb Save Summer" (2014)
- Jane Lynch voices Mrs. Johnson
- Joel McHale voiced Norm head prototype in the episode "Candace Disconnected" (2011)
- Jamie Oliver voiced himself in the episode "Meatloaf Surprise" (2011)
- Madison Pettis voices Adyson
- Caroline Rhea voices Linda
- Seth Green voices Monty Monogram
- Brenda Song voiced Wendy in the episode "Unfair Science Fair" (2009)
- French Stewart voiced Gaston Le Mode in the episode "Run Away Runway" (2008)
- Jon Stewart voiced Mittington Random in the episode "The Klimpaloon Ultimatum" (2014)
- Ben Stiller voiced Khaka Peü Peü in the episode "The Beak" (2010)
- Ashley Tisdale voices Candace