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SpongeBob SquarePants is an animated series that debuted on Nickelodeon in 1999 and soon became one of the channel's linchpin series. The title character appeared in the We Are Family music video alongside Muppet characters.
- In a 2004 promotional magazine for The SpongeBob SquarePants Movie, Patchy the Pirate hosts his own short section in which he names off the great movie pirates, including Tim Curry's performance as Long John Silver in Muppet Treasure Island.
- In It's a Very Merry Muppet Christmas Movie, while watching Kermit's flight on a video screen, the Boss tells Daniel he's "just lucky SpongeBob isn't on." Daniel soon tells her that he loves SpongeBob.
- Brad Abrell voiced Bubble Buddy in "Bubble Buddy" and "Bubble Buddy Returns"
- Alec Baldwin voiced Dennis in The SpongeBob SquarePants Movie (2004)
- Antonio Banderas played Burger Beard in The SpongeBob Movie: Sponge Out of Water (2015)
- Tim Blaney voiced the Goofy Goober in The SpongeBob SquarePants Movie (2004)
- David Bowie voiced Lord Royal Highness in "Atlantis SquarePantis"
- Alton Brown voiced Nicholas Withers in "House Fancy"
- Tim Conway voices Barnacle Boy
- Rosario Dawson played herself in "Truth or Square"
- Johnny Depp voiced Jack Kahuna Laguna in "SpongeBob SquarePants vs. The Big One"
- Bill Fagerbakke voices Patrick Star
- Craig Ferguson played himself in "Truth or Square"
- Tina Fey played herself in "Truth or Square"
- John Goodman played Santa in "It's a SpongeBob Christmas!"
- David Hasselhoff appeared as himself in The SpongeBob SquarePants Movie (2004)
- Tim Hill was a series writer and co-wrote The SpongeBob SquarePants Movie (2004)
- Ray Liotta voiced Bubble Poppin' Boys leader in the episode "WhoBob WhatPants?"
- Pat Morita voiced Master Udon in the episode "Karate Island"
- Andrea Martin voiced Miss Priss in "Banned in Bikini Bottom"
- Brian Doyle-Murray voiced the Flying Dutchman
- John O'Hurley voiced King Neptune in "Neptune's Spatula" and "The Clash of Triton"
- Patrick Pinney voiced Painty the Pirate, the buccaneer artwork who sings the series' theme song
- Dennis Quaid voiced Grandpa Redbeard in " Grandpappy the Pirate"
- Andy Samberg voiced Colonel Carper in "Hello Bikini Bottom!"
- Amy Sedaris voiced Ma Angler in "Trenchbillies"
- Gene Shalit played Gene Scallop in the episode "The Krusty Sponge"
- Jeffrey Tambor voiced King Neptune in The SpongeBob SquarePants Movie (2004)
- Frank Welker supplied voices in "The Smoking Peanut", "My Pretty Seahorse", and "I Had an Accident"
- Robin Williams played himself in "Truth or Square"
- Don Yanan played a mime in "Truth or Square"