Ross Mathews is a regular panelist on Chelsea Lately, having coming to popularity as Ross the Intern on Tonight Show under Jay Leno. Other appearances include 1 vs 100, Days of our Lives, and host of the offical The Amazing Race webshow.

In 2011, Mathews introduced a "Rainbow Connection" duet by Darren Criss and Kermit the Frog, during an E! network lead up to their red carpet show for the Academy Awards Ceremony telecast.