Diller was one of the first women to establish a long and successful career in comedy. She earned a star on the Hollywood Walk of Fame in 1993.
She retired from the stand-up circuit in 2002 due to ill health. Her film career included lending her voice to multiple projects including the Rankin/Bass Halloween film Mad Monster Party, Pixar's A Bug's Life, The New Scooby Doo Movies, Hey, Arnold!, and Family Guy. Feature film work included three films with Bob Hope, and The Silence of the Hams.