The National Aeronautics and Space Administration (NASA) is an agency of the United States government, responsible for the nation's public space program. Established on July 29, 1958, by the National Aeronautics and Space Act. NASA often works with space agencies from foreign countries such as Japan and Russia for a number of missions.
In addition to the space program, it is also responsible for long-term civilian and military aerospace research. Since February 2006 NASA's self-described mission statement is to "pioneer the future in space exploration, scientific discovery, and aeronautics research."
- Pigs in Space: Space Shuttle Columbia — sketches written and performed in 1981 exclusively for astronauts in space
- Big Bird on Space Shuttle Challenger — Caroll Spinney considered for space mission in mid-1980s
- Mars rovers success — the Henson Company sends a letter of congratulations to NASA's JPL in 2004
- NASA Tweetup — Elmo attends the final launch of Space Shuttle Atlantis in 2011
- Orion Flight Test — NASA sends mementos from Sesame Street into space in 2014
- Inter-American Development Bank — Lola attends an educational event with NASA engineers
- Several NASA astronauts have appeared in Muppet/Sesame productions including Buzz Aldrin, Ricky Arnold, Frank Caldeiro, Soichi Noguchi (on a joint NASA/JAXA mission), Sally Ride, and Mario Runco.
- In a 1992 "Wish You Were Here" segment on Sesame Street, Gabi and Miles take a tour of the Kennedy Space Center. They learn about how rockets are launched into space, along with a group of other kids. Miles works at Mission Control, while Gabi pretends to be an astronaut.
- Sesame Street used stock footage from NASA:
- Muppet Babies used stock footage from NASA:
- Footage of a Mercury rocket launch is used in "Muppetland" followed by footage of astronauts walking on the Moon, despite the fact that astronauts traveled to the moon in vehicles launched on a Saturn V rocket.
- To illustrate Baby Gonzo's claim that a typewriter is space technology in "Romancing the Weirdo", footage of a Space Shuttle launch is used alongside shots of NASA's ground team at Mission Control.
- "Puss 'n Boots 'n Babies" used footage of a Space Shuttle landing to mirror Baby Kermit and Baby Gonzo's paper airplane.
- Skeeter treats the Babies to a "launch party" in "Happy Birthday, Uncle Piggy" by way of a trip to space. Footage of Mission Control and a Space Shuttle launch is used for their ascent, and footage of a Solid Rocket Booster is used for their landing.
- Kermit the Frog visited NASA's Johnson Space Center in Texas as part of his 50th anniversary world tour in 2005. Kermit also appeared in NASA promotional material on the moon.
- On Earth Day in 2014, NASA asked everyone on the planet to participate in a Global Selfie. Sesame Workshop submitted a photo of Elmo taken on the stoop of 123 Sesame Street. NASA composited all the #GlobalSelfie images posted to social media and used Elmo in the final product. Of the two images created, Elmo can be seen in the Earth on the right, on the upper-left hand side, just Northeast of the Mediterranean Sea.
- Joe Mathieu depicts NASA's Saturn V rocket in The Sesame Street Dictionary to illustrate the definition of the word "rocket".
- Dr. Julius Strangepork writes Kermit a letter in the Summer 1983 issue of Muppet Magazine from the Johnson Space Center. He and Captain Link Hogthrob had intended to go to the island of Nassau for "de girls in de bikinis", but Link set a course instead for NASA. While they wait for The Swinetrek to be repaired, they take a tour and learn that Sally Ride will soon embark on her first mission to space. The letter arrives with bits of memorabilia including photos of the Space Shuttle, a NASA "meatball" patch, an Apollo Service Module toy, a Saturn V toy, pictures of astronauts Joseph Kerwin, Paul Weitz, and Jerry Carr (with an illustration of Link torn and pasted in), and a bill for $748,386,385.98 to repair the Swinetrek's coffee machine and water cooler.
- Sesame Street's WASA, the Worm Air and Space Agency, is a version of NASA staffed entirely by worms.
- Telly Monster's Uncle Tommy plays an astronaut assisted by two NASA employees (one of whom is David Rudman making a cameo) in the Sesame Street video Telling the Truth. Dennis Quaid plays Uncle Tommy, who had portrayed NASA astronaut Gordon Cooper in The Right Stuff fourteen years earlier.
- In Farscape, John Crichton is a an astronaut for IASA, a fictional organization modeled after NASA. Crichton's father Jack is a retired NASA astronaut.
- During a September 20, 2011 appearance on Good Morning America, Cookie Monster was watching the skies, looking out for satellites. This was a reference to the Upper Atmosphere Research Satellite making news for its expected re-entry in the following days and NASA's warning of a small potential risk of impact (the debris field was later identified in the Pacific Ocean).
- In The Muppets, Walter and Gary have a model of the Saturn V rocket, the only vehicle that has ever carried humans beyond low Earth orbit.
- Murray Monster visits Rocket Garden at the New York Hall of Science in Sesame Street Episode 4257 where he admires a Mercury Atlas rocket and a Gemini Titan rocket.
- Bunsen and Beaker were asked on Twitter in January 2016 if they'd ever wanted to work for NASA. Bunsen replied, "Yes, but unfortunately NASA doesn't feel the same way about us." 
- A rubber chicken named Camilla Corona is the mascot of NASA's Solar Dynamics Observatory. "Camilla", named after Camilla the Chicken from The Muppet Show, and "Corona" for the sun's plasma atmosphere. Elmo had his picture taken with Camilla during his visit to NASA in July 2011.
Sesame Workshop and NASA have partnered in a number of social media campaigns by way of sharing content on their various social media outlets in the interest of educational exposure.
- In January 2010, Cookie Monster wrote on Sesame Street's official Twitter account, "Sometimes Moon look like giant cookie. Must look into joining space program." NASA responded a short time later from their official Twitter feed with information on how to join the space program.
- To celebrate the 40th anniversary of NASA's first selection of female astronauts, Sesame Street’s Facebook page posted an image of Rosita wearing a space suit on January 16, 2018. The image is actually a manipulated photo of Neil Armstrong during the Gemini VIII mission in May of 1965. NASA's Johnson Space Center shared the post from their Facebook account. "Thank you to these incredible women for continuing to serve as great role models for girls and boys everywhere to dream BIG and reach for the stars! 💫"
- ↑ personal communication via Scott Hanson
- ↑ "Cookie Monster storms Twitter as @sesamestreet gains a following", LA Times blogs, April 9, 2010.