Mark Twain was the pen name of writer Samuel Langhorne Clemens (1835-1910), one of the foremost American novelists and humorists. Twain's best known works, primarily set in the pre-Civil War South, include The Adventures of Tom Sawyer, The Adventures of Huckleberry Finn, Life on the Mississippi, A Connecticut Yankee in King Arthur's Court, Pudd'nhead Wilson, and The Prince and the Pauper, among others.
- The Sesame Street Storytime Calendar 1982 features an illustration based on The Adventures of Tom Sawyer, depicting Ernie and Bert as Tom and Huck on a raft. Which is which is never specified.
- In the seventh season Muppet Babies episode "Buckskin Babies," Twain's characters are spoofed, with Baby Scooter as Scoot Sawyer, Baby Bean as Hucklebunny, and Baby Piggy as Aunt Piggy (Aunt Polly). Scoot and Hucklebunny's attempts to whitewash a fence are continually thwarted.
- The Muppet Babies book Good Knight, Sir Kermit involves Baby Kermit meeting a look-alike knight, and trading places. The basic premise was borrowed from Twain's The Prince and the Pauper.
- In the 2002 book Look and Find Elmo, Rubber Duckie is visited by a crowd of duckie friends. One of the visiting ducks is Duckleberry Swim, who wears a tattered hat and steers his raft through the bubbles in Ernie's bathtub.