As with most Spanish dubbed cartoons, no title cards were altered; instead, a voice-over announcer read the Spanish translation for all on-screen text. A tie-in comic book, also called Los Pequeños Muppets, was first published by Grupo Editorial Vid in 1989.
- Arturo Mercado as Baby Kermit (René), Baby Rowlf (Rufo), and Spider-Man
- Diana Santos as Baby Piggy and Baby Beaker (Beto).
- Héctor Lee as Baby Gonzo and Baby Animal (first few seasons)
- Alfonso Obregón as Baby Gonzo and Baby Animal (later seasons)
- Francisco Colmenero as Baby Fozzie and text narrator
- Rocío Garcel as Skeeter (Kika)
- Raúl Aldana as Baby Scooter (Kiko), Baby Bunsen (Basilio), and Baby Bean Bunny
- Nancy McKenzie as Nanny
- Araceli de León as Baby Robin
- Luis Puente as Stan Lee