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Los Muppets en el Espacio was the Spanish-language dub of Muppets from Space, as released in Mexico to theaters and on home video. The video, released in a clamshell, was also available in the United States of America.
- Ernesto Lezama as Gonzo
- Raul Aldana as Kermit the Frog (Rene), Rizzo the Rat, Johnny Fiama, and Scooter
- Diana Santos as Miss Piggy
- Herman López as Dr. Bunsen Honeydew (Basilio)
- Nancy McKenzie as Shelley Snipes
- Esteban Siller as K. Edgar Singer
- Francisco Colmenero as Bobo the Bear/Rentro, The Swedish Chef, and Narrator
- Ricardo Tejedo as Pepe
- Yamil Atala as Robin the Frog
- José Gilberto Vilchis as Dr. Tucker
- Arturo Mercado as Dr. Phil Van Neuter, Sal Minella, and Cosmic Fish #1
- Humberto Vélez as Bubba
- Jesse Conde as Martin
- Sergio Bonilla as Gate Guard
- Angela Villanueva as Security Guard
- Javier Rivero as Cosmic Fish #2
- María Fernanda Morales as Joey
- Luis Daniel Ramirez as Pacey
- Benjamin Rivera as Hippie