Life is an American magazine published in some form since 1883. In 1936 it was purchased by the owner of Time and has together jointly published a number of products including magazines, records and home video.
- The October 31, 1969 issue featured a brief article on the upcoming premiere of Sesame Street: "In just an hour a day, fewer learning cavities." The article included a photo of Jim Henson in his workshop, with Ernie, Bert, Kermit the Frog and Beautiful Day Monster.
- In August 1980, Miss Piggy appeared on the cover in a mock campaign for President of the United States, supported by Kermit and a number of enthusiastic frogs.
- Kermit appeared on the cover of the July 1990 issue to commemorate the life of Jim Henson shortly after his passing. The issue featured an article by Stephen Harrigan accompanied archive photos and at least one new photo featuring a number of Henson's characters holding his picture approximately from the time period in which he originated the character. 
- Oscar the Grouch was a guest editor for the online November 5, 2009 edition, where he supplied "'Sesame' Stories", a pictorial scrapbook of his memories of Sesame Street's 40th Anniversary.
- A special commemorative issue, Life Farewell: Remembering the Friends We Lost in 2012, includes a tribute to Jerry Nelson on the last page. Prominently featured is a painting by Caroll Spinney depicting Nelson and some of his Sesame Street characters (The Count, Herry Monster, Fat Blue, and the Amazing Mumford) with a teary Big Bird looking upward.
- Miss Piggy appears in a parody cover in The Miss Piggy Cover Girl Fantasy Calendar in 1981. She is seen parachuting into an army camp as entertainment during World War II.
- In episode 110 of The Muppet Show, during the panel discussion of the meaning of life, Harvey Korman mentions that he owns the last issue of Life magazine.