Instances where the Muppet characters interact with animated characters (whether traditional, stop-motion or computer generated) in the same physical space onscreen.
|Picture||Production / Description|
| Muppet Babies: "The Incredible Shrinking Weirdo"
This episode features a scene where a live-action adult Kermit interacts with an animated Baby Gonzo. A clip from The Muppet Show (episode 223) was used, with Frank Welker dubbing new lines for Kermit and with Baby Gonzo matted into the scene.
| The Jim Henson Hour and Muppet*Vision 3D
Waldo C. Graphic, a computer animated being, interacts with the Muppets in both productions.
|The Muppets at Walt Disney World|
| Elmo's World
All of the furnishings Elmo interacts with in his room - Door, Shade, Drawer, TV and Computer - are computer generated. In the 2017 rebooted segments, Elmo interacts with a two-dimensionally animated character, Smartie.
| Kermit's Swamp Years
Kermit's interactions with Horace D' Fly.
| Sesame Sings Karaoke
Elmo interacts with an animated music note in the framing material.
| What's the Name of That Song?
A lengthy scene of the video sees Elmo and Super Grover interacting with animated numbers and letters.
|A Sesame Street Christmas Carol|
|3, 2, 1 Let's Go|
| Elmo the Musical
Elmo's co-star of the segments, Velvet, is computer animated. Several of the characters appearing in the segment are computer animated as well, including Moby Pink, the Rhombus of Recipes and Hetti the Yeti.