Mandel also appeared in Word of the Day segment during Sesame Street Season 38, discussing the word "ticklish." In the same season, Mandel was caricatured as Howie Eatswell in a parody of Deal or No Deal.
Mandel's other TV credits include the role of Dr. Wayne Fiscus on St. Elsewhere for the entire run of the series (1982-1988) and the voices of Bobby and Dad Generic on the animated series Bobby's World, which Mandel created, as well as guest spots on Lois & Clark: The New Adventures of Superman (as Mxyzptlk) and The Outer Limits. Films include Gremlins and Gremlins 2 (as the voice of Gizmo), Blake Edwards' A Fine Mess, Little Monsters, and Tribulation.