- In February 2016, Elmo appeared in a web video to help promote the show's daily “Ham4Ham” lottery. Elmo visited the set of Hamilton to sing "The Story of Tonight" with Christopher Jackson (George Washington).
- Miss Piggy told Harry Connick, Jr. on his show in December 2016, that she turned down a role in Hamilton because she refuses to do anything with the word "ham" in it.
- Michael Aarons is music coordinator for the show.
- Utkarsh Ambudkar originated the role of Aaron Burr in the show's 2013 workshops.
- Randy Cohen programmed keyboards and synthesizer for the show.
- Renée Elise Goldsberry originated the role of Angelica Schuyler.
- Christopher Jackson originated the role of George Washington.
- Taran Killam currently plays the role of King George III.
- Alex Lacamoire is the musical director, arranger, orchestrator, conductor, and plays keyboards.
- Lin-Manuel Miranda wrote and co-arranged the music, lyrics and book for the play and originated the role of Alexander Hamilton.
- Anja Wood plays cello in the orchestra.