Grey's Anatomy is a television series about a group of hospital interns that has aired on ABC since 2005.
- Sesame Street spoofed the series in a 2007 episode as "A's Anatomy", starring Doctor Grover attempting surgery on the letter A.
- The French series Muppets TV spoofed the series in a recurring sketch titled "Muppets Anatomy", using the Grey's Anatomy theme song during the title. The doctors are played by Kermit the Frog, Miss Piggy, Clifford, Fozzie Bear, Swedish Chef, and Gonzo. In one episode, Clifford and Fozzie Bear operate on guest star, Pascal Obispo, changing his singing voice by using a screwdriver on his neck.
- Diahann Carroll played Jane Burke in five episodes (2006-2007)
- Tyne Daly played Carolyn Shepherd in "Sympathy for the Devil" (2009)
- Taye Diggs played Dr. Sam Bennett
- James Frawley directed episodes (2007-2009)
- Seth Green played Nick Hanscom in "Crash Into Me" (2007)
- Ellen Pompeo plays Dr. Meredith Grey
- Mariette Hartley played Betty Kenner in "Dream a Little Dream of Me" (2008)
- Mimi Kennedy played Verna Bradley in "Bring the Pain (2005)
- T. R. Knight played Dr. George O'Malley (2005-2009)
- Sandra Oh plays Dr. Cristina Yang
- Cheech Marin played Otis Sharon in "Where the Wild Things Are" (2008)
- Kellie Martin played Julie Zelman in "No Good at Saying Sorry (One More Chance)" (2009)
- Sara Ramírez plays Dr. Callie Torres (2006-)
- Kim Raver played Dr. Teddy Altman (2009-2012)
- Richard Roundtree played Donald Burke in "I Am a Tree" (2006)
- Isaiah Washington played Dr. Preston Burke (2005-2007)
- Jesse Williams plays Dr. Jackson Bailey (2009-)
- Chandra Wilson plays Dr. Miranda Bailey