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Born in Fort Worth, Texas Deen's work has been exhibited at various Texas galleries, at the Guggenheim in Los Angeles, and in New Zealand. Deen is also a poet and a musician, and her published poetry is often accompanied by her illustrations. Her Season of the Western Witch poetry collection has been released with a CD of Deen's songs. She contributed to underground comics, such as Raw and Cannibal Romance, and was included in the 1995 anthology The Narrative Corpse alongside the likes of Matt Groening, R. Crumb, and Mort Walker.