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Most active in TV, Regen has had regular roles on the short-lived sitcoms Whoopi! (with Whoopi Goldberg) and Sherri, as well as guest appearances on CSI: Crime Scene Investigation, Sex and the City, Malcolm in the Middle, Third Watch, and Entourage. Her film resume is highlighted by the 1994 movie Léon: The Professional (playing Natalie Portman's sister).