From Muppet Wiki

The Day Care Center on Sesame Street has, like Hooper's Store, changed hands several times over the years. It was first introduced in Season 21, when Maria and Luis sought a daycare provider for Gabi. The original owner was the matronly Lillian, who also cared for Muppet toddlers as well. By Season 25, Lillian had departed, and the new owner was Angela, who had a toddler of her own, Kayla. The Day Care Center became more prominent as a physical presence, as part of the new "Around the Corner" sets. Two years later, Angela and her family likewise moved, and Gina, already a comforting presence for the kids on Sesame Street, took over for several years, before becoming a veterinarian. The Day Care has been dropped for the present.