Daisy-Head Mayzie is a little girl who has daisy sticking out of her head. She introduces her self to Larry Nooly after he introduces himself. They play for a while till The Grinch ruins it for them. Daisy-Head Mayzie is based on a book by Dr. Seuss called Daisy-Head Mayzie.

She was featured in the Wubbulous World of Dr. Seuss episode "The Guest" with her mom, Mrs. Casaba.