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Making his film debut in 1975 as mental patient Taber in One Flew Over the Cuckoo's Nest, Lloyd went on to appear as "Reverend" Jim Ignatowski in the sitcom Taxi (for which he won two Emmy Awards), Doc Emmett Brown in the Back to the Future movies (a role which he reprised in The Earth Day Special), Uncle Fester in The Addams Family (1991) and its sequel, and the villainous Judge Doom in Who Framed Roger Rabbit?.
Lloyd's other film credits include To Be or Not to Be (with Mel Brooks and Charles Durning), Clue (as Professor Plum, with Tim Curry and Lesley Ann Warren), the 1993 film Dennis the Menace (as Switchblade Sam), and Things to Do in Denver When You're Dead. Returning to television, Lloyd played Professor Harold March on the short-lived FOX sitcom Stacked, and can be heard as the evil Hacker in the Nelvana animated series Cyberchase, as seen on PBS.
On March 26th 2012, The Jim Henson Company annouced that a Sid the Science Kid Movie is in the works starring Christopher Lloyd as Proffesor Bonanodon.