CERN is the world's largest high-energy physics laboratory, established in 1954. It is home to the Large Hadron Collider, a particle accelerator 17 miles in circumference under Switzerland and France.

In The Muppets, Dr. Bunsen Honeydew and Beaker are shown to be working on the LHC when Kermit the Frog and his friends arrive to recruit them for a show to save the Muppet Theatre.