Barbara Bush (1925-2018) was a First Lady of the United States of America. She appeared on Sesame Street in Season 21 with Big Bird, the Count and the Kids, reading Peter's Chair. She also appeared in a celebrity montage singing "Sing" in the documentary Sing! Sesame Street Remembers Joe Raposo and His Music.
Bush contributed a "Bologna for a Cocktail Buffet" recipe for the 1996 cookbook, In the Kitchen with Miss Piggy. She appeared with her husband, former President George H. W. Bush, in a video introduction to the 1990 animated anti-drug television special Cartoon All-Stars to the Rescue.
Sesame Street Live characters have visited the Barbara Bush Children's Hospital/Maine Medical Center.
- A still of Barbara Bush and her husband were used in the Muppet Babies episode "Happy Birthday, Uncle Piggy."
- In the book The Muppets Make Puppets!, Barbara and her husband were caricatured as George and Barbara Brush.
- An Anything Muppet caricature of her appears as President Elmo's "third lady" in the "Elmo the Musical" segment, "President the Musical."