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Imagery associated with the series was used in a spoof featured on a Muppet Celebrity T-shirt in 2005, crediting Jennifer Garner as inspiration for the design.
Several actors who appeared on Alias have also appeared in Muppet/Henson productions.
- Victor Garber played Jack Bristow
- Jennifer Garner starred as Sydney Bristow
- Joel Grey played Another Mr. Sloane
- Stana Katic played a flight attendant in "Façade"
- Michael McKean played Dr. Atticus Liddell
- Roger Moore played Edward Poole
- Richard Roundtree played Brill
- Isabella Rossellini played Katya Derevko
- Quentin Tarantino played McKenas Cole