- In episode 202 of Muppets Tonight, Meepzorp tells Clifford he "turned down 3rd Rock" to be in the "Co-Dependence Day" sketch.
- In the episode "My Mother the Alien," Sally Solomon takes a baby (and Harry) to a toy store. Throughout the scene, Elmo and Cookie Monster dolls can be seen in the background.
- The DVD for the show's sixth season includes a featurette titled "Six Seasons of Memories." One of the feature's subsections is referred to as "It's Not Easy Being Me: The Challenge of Playing an Alien."
- John Aylward played a registrar in the episode "Dick the Vote" and the Chancellor in "B.D.O.C."
- Roseanne Barr played Janet in "Fun with Dick and Janet"
- Jason Carter played Seth in the episodes "A Friend in Dick" and "Eleven Angry Men and One Dick"
- John Cleese played Liam Neesam
- Cindy Crawford played Mascha in the episode "36! 24! 36! Dick!"
- Jane Curtin played Mary Albright
- Joseph Gordon-Levitt played Tommy Solomon
- Mark Hamill played himself in the episode "Fifteen Minutes of Dick"
- John Lithgow played Dick Solomon
- Marianne Muellerleile played Lucy
- Randy Newman composed the song "Life Has Been Good to Me" for, and appeared in, "A Nightmare on Dick Street"
- John Raitt played Gil in "Frozen Dick"
- William Shatner played the Big Giant Head/Stone Phillips
- French Stewart played Harry Solomon
- George Takei played himself in "Hotel Dick"