2001: A Space Odyssey is a science fiction story by Arthur C. Clarke and a movie directed by Stanley Kubrick.
- The puzzle solutions page for Jim Henson's Muppets Annual 1980 features an illustration of primates looking at the answers on a large, black monolith. One of them sports an idea bulb over its head with a bone at its feet.
- The music video for "I'm Gonna Always Love You" begins with Baby Piggy encased in an egg-like sphere juxtaposed with the Earth (which she is subsequently slammed into) much like the ending of 2001. The scene is underscored with "Also sprach Zarathustra", famously used in the film.
- In episode 211 of Muppets Tonight, Andie MacDowell has requested to play a southern belle on the show. Kermit attempts to oblige, but the Muppets Tonight writers keep getting it wrong. When they finally hand in a suitable script, Kermit lets them touch the monolith. As they go crazy, hitting it with bones, "Also sprach Zarathustra" by Richard Strauss plays, an homage to the film.
- The AL-1995 Plus Tax is a reference to HAL 9000, the computer from the film.